2 Week South America Tour Packages
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South America itineraries for 2 weeks
Compiled by

NinaSouth America travel expert at TourRadar
14 Day South America Itinerary, incl. Santiago and Rio de Janeiro
South America's iconic landmarks unfold over 14 days: Santiago's historic center, Ushuaia's Beagle Channel, Buenos Aires' cultural landmarks, Iguazu Falls from the Brazilian perspective, and Rio's famous sights. Features 4-star accommodations, 13 breakfasts, and strategic flights.
- Days 1-2
Santiago
Begin your trip in Chile's capital. Get to Plaza de Armas around 8 AM to avoid crowds. Take the San Cristobal Hill cable car before 11 AM for clear city views without the afternoon haze. Visit Mercado Central at lunch when you'll find the freshest seafood. A helpful tip from a traveler: "The funicular up Santa Lucia Hill can have long waits—take a taxi to the top and walk down through the gardens instead."
- Days 3-4
Ushuaia
Take a 4-hour flight to the world's southernmost city. Dress in layers since even summer can be cold. Book a Beagle Channel catamaran trip to see sea lions and penguins on Martillo Island. The penguins nest here from September to April. If you get seasick easily, bring motion sickness medication. Your camera will need waterproof protection from the sea spray.
- Days 5-7
Buenos Aires
Fly 3.5 hours to Argentina's vibrant capital. Visit San Telmo first, but plan for the Sunday market early before it gets packed. Take a morning boat to the peaceful Tigre Delta. For authentic tango, try El Viejo Almacen instead of the typical tourist spots. A local tip: "Skip the overpriced Puerto Madero restaurants—the best steaks are in Palermo at neighborhood parrillas."
- Days 8-9
Iguazu Falls
A 2-hour flight takes you to these incredible waterfalls. Stay on the Brazilian side for better views. Get to Devil's Throat right when it opens at 9 AM to beat the crowds. Your electronics will need a dry bag because the viewing platforms get very wet. One visitor notes: "The helicopters tours get booked days ahead in peak season—reserve before arrival if it's a must-do."
- Days 10-14
Rio de Janeiro
Reach your final stop with a 2-hour flight. Take the first 8 AM tram to Christ the Redeemer or you'll face long lines. Watch the sunset from Sugarloaf Mountain. Hit Copacabana beach in the morning before the afternoon winds pick up sand. A traveler suggests: "The walk from Copacabana to Ipanema along the beachfront is gorgeous but very hot midday—do it early or near sunset."
14 Day South America Itinerary, incl. Buenos Aires and Rio de Janeiro
South America's finest destinations span 6 cities across 3 countries. The route features UNESCO World Heritage sites, from Colonia's Barrio Historico to Iguazu's massive waterfall system. Includes varied accommodations from traditional estancias to modern hotels, suitable for ages 18+.
- Days 1-2
Buenos Aires
Start your adventure in Argentina's capital with a walk through the historic Microcentro district. Visit the Palermo neighborhood at 8 PM when locals eat dinner at the city's best steakhouses. The next day, take a morning tour of Teatro Colon to avoid crowds. Set aside 2-3 hours for the magnificent Ateneo Bookshop, a converted theater that ranks among the world's most beautiful bookstores.
- Days 3-4
Uruguay
Cross the Rio de la Plata on a 1-hour ferry to Colonia del Sacramento. Visit the historic quarter early morning before other tourists arrive. A climb up the lighthouse offers great city views for a small fee. Take a 3-hour bus to Montevideo and visit Mercado del Puerto at lunchtime for excellent grilled meats.
- Days 5-7
Uruguayan Estancia
Experience authentic ranch life inland. Farm work starts at 6 AM, so bring sturdy boots if you plan to participate. You'll stay in basic shared rooms with family-style meals. A recent visitor shared: "Waking up to roosters and helping milk cows gave me a real taste of gaucho life. The home-cooked meals were incredible."
- Days 8-9
Iguazu Falls
Visit both the Brazilian and Argentine sides of these spectacular falls. Start in Brazil for the big picture views, then explore Argentina's walkways the next day. Take a waterproof bag because you'll get wet. Photos look best between 10 AM-2 PM when sunlight hits the mist. Book your boat ride early since spots fill up quickly.
- Days 10-12
Paraty & Ilha Grande
Fly to São Paulo, then travel 4-5 hours to historic Paraty. Take a 1.5-hour ferry to Ilha Grande, a car-free island paradise. Good walking shoes are essential for reaching the best beaches. The 2-hour hike to Lopes Mendes beach rewards you with pristine sand and surf. Buy supplies in Paraty since everything costs more on the island.
- Days 13-14
Rio de Janeiro
14 Days in South America, incl. Atacama and Machu Picchu
The wonders of 12 South American cities unfold over 14 days, from Chile's Atacama to Peru's Cusco. Highlights include Salar de Uyuni's vastness, Lake Titicaca's cultural richness, and Machu Picchu's ancient wonder. Includes carefully planned accommodations and multilingual guided tours.
- Days 1-2
Atacama Desert, Chile
Fly into Calama (2,300m) and head to San Pedro de Atacama. Book an early afternoon arrival to avoid the strongest desert sun. The salt dunes offer beautiful sunset photos. Pack a light jacket as temperatures drop quickly at night. Spend day two exploring Rainbow Valley and swimming in the Baltinache Lagoons. Remember to reapply sunscreen often. The high altitude makes UV rays much stronger here.
- Days 3-5
Bolivia Salt Flats
Cross to Bolivia at Hito Cajon border post. Bring small USD bills for visa fees. Visit Sol de Mañana Geysers in the early morning when steam visibility is best. Pack waterproof sandals for the Polques hot springs. The Salar de Uyuni is best visited between July and October when conditions are driest. Take the night bus to La Paz to save time and a hotel night.
- Days 6-7
La Paz & Lake Titicaca
- Days 8-10
Sacred Valley
- Days 11-14
Machu Picchu Region
Stay in Ollantaytambo before visiting Machu Picchu. The Maras salt mines look best in mid-morning sunlight. Take the first bus to Machu Picchu at 5:30 AM to avoid crowds and afternoon rain. A recent visitor noted: "The morning mist gradually lifting from the ruins created an unforgettable scene. Getting there early meant we could explore the agricultural terraces before they became crowded."
What people love about 2 week South America tours
- 12 Day Argentina & Brazil
I loved the tour! Really interesting!! Just as planned.
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